By advocating and sharing the latest peer-review research findings on our ingredients, we underscore our commitment to transparency, scientific integrity, and the promotion of knowledge related to natural products, brain health, and healthy aging.
By advocating and sharing the latest peer-review research findings on our ingredients, we underscore our commitment to transparency, scientific integrity, and the promotion of knowledge related to natural products, brain health, and healthy aging.
This review highlights the health benefits of Cannabinol (CBN), showcasing the ingredient’s non-psychoactive therapuetic potential (Khouchlaa, 2024).
This research highlights that Cannabinol (CBN) is a novel inhibitor of oxytosis/ferroptosis, directly targeting mitochondria for healthy brain aging.
It also shows that CBN protects crucial aspects of mitochondrial function for neuroprotection (Liang & Maher, 2022).
This research highlights that Cannabinol (CBN) is a novel inhibitor of oxytosis/ferroptosis, directly targeting mitochondria for healthy brain aging. It also shows that CBN protects crucial aspects of mitochondrial function for neuroprotection (Liang & Maher, 2022).
This study found that orally ingested Cannabinol (CBN), at 50 mg is a safe and effective alternative for the improvement of sleep (Kolobaric et al., 2024).
This study found that orally ingested Cannabinol (CBN), at 50 mg is a safe and effective alternative for the improvement of sleep (Kolobaric et al., 2024).
This research demonstrated that Cannabinol (CBN) protects nerve cells from damage caused by oxytosis/ferroptosis, without relying on cannabinoid receptors and has the potential to rescue mitochondria from dysfunction. It was found that CBN specifically targets mitochondria, preserving critical functions like redox regulation, calcium uptake, membrane potential, bioenergetics, biogenesis, and helps maintain mitochondrial fusion and fission dynamics, which are often disrupted during neurodegeneration (Liang et al., 2022).
This research demonstrated that Cannabinol (CBN) protects nerve cells from damage caused by oxytosis/ferroptosis, without relying on cannabinoid receptors and has the potential to rescue mitochondria from dysfunction. It was found that CBN specifically targets mitochondria, preserving critical functions like redox regulation, calcium uptake, membrane potential, bioenergetics, biogenesis, and helps maintain mitochondrial fusion and fission dynamics, which are often disrupted during neurodegeneration (Liang et al., 2022).
This detailed review suggests that studying natural products targeting mitochondria is crucial to enhance our understanding of supporting brain health and promoting healthy aging (Liang et al., 2021).
This detailed review suggests that studying natural products targeting mitochondria is crucial to enhance our understanding of supporting brain health and promoting healthy aging (Liang et al., 2021).
This research discovered that Cannabinol (CBN) is a potent neuroprotector, and highlighted the importance of studying non-psychoactive natural products to enhance our understanding of brain health and healthy aging (Schubert et al., 2019).
This research discovered that Cannabinol (CBN) is a potent neuroprotector, and highlighted the importance of studying non-psychoactive natural products to enhance our understanding of brain health and healthy aging (Schubert et al., 2019).
We focus on highlighting the most significant healthy aging findings related to our ingredients. While some relevant peer-reviewed studies may not be included in our current list, we regularly update our references to ensure we’re sharing the latest research findings.
Not seeing a study or peer- reviewed finding that you think should be included? Reach out to us directly on our Contact page.
Yes! Memory Guard Plus is interested in healthy aging research initiatives. We recognize the importance of supporting scientific studies in the fields of brain health and age-related cognitive decline. By collaborating with researchers and experts, we aim to contribute valuable insights that can inform our ingredient choices and the development of effective formulations. Our commitment to supporting and sharing peer-reviewed research ensures that our products are evidence based, ultimately benefiting the health and well-being of our members.
For more information on collaborations, feel free to reach out to us directly on our Contact page.
A detailed list of citations of our featured peer-review articles is available below.
Khouchlaa, A., Khouri, S., Hajib, A., et al. (2024), Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review. Industrial Crops and Products, 204: 118359. https://doi.org/10.1016/j.indcrop.2024.118359
Liang, Z. and Maher, P. (2022), Targeting mitochondria for healthy brain aging: a case study of non-psychoactive cannabinoids to rescue mitochondrial dysfunction in Alzheimer’s disease. Alzheimer’s Dement., 18: e062544. https://doi.org/10.1002/alz.062544
Kolobaric, A.; Saleska, J.; Hewlings, S.J.; Bryant, C.; Colwell, C.S.; D’Adamo, C.R.; Chen, J.; Pauli, E.K. A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep. Pharmaceuticals 2024, 17, 977. https://doi.org/10.3390/ph17080977
Liang, Z., Soriano-Castell, D., Kepchia, D., Duggan, B. M., Currais, A., Schubert, D., & Maher, P. (2022). Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. Free Radical Biology and Medicine, 180, 33-51.
https://doi.org/10.1016/j.freeradbiomed.2022.01.001
Liang, Z., Currais, A., Soriano-Castell, D., Schubert, D., & Maher, P. (2021). Natural products targeting mitochondria: Emerging therapeutics for age-associated neurological disorders. Pharmacology & Therapeutics, 221, 107749.
https://doi.org/10.1016/j.pharmthera.2020.107749
Schubert, D., Kepchia, D., Liang, Z. et al. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease. Mol Neurobiol 56, 7719–7730 (2019). https://doi.org/10.1007/s12035-019-1637-8
We focus on highlighting the most significant healthy aging findings related to our ingredients. While some relevant peer-reviewed studies may not be included in our current list, we regularly update our references to ensure we’re sharing the latest research findings.
Not seeing a study or peer- reviewed finding that you think should be included? Reach out to us directly on our Contact page.
Yes! Memory Guard Plus is interested in healthy aging research initiatives. We recognize the importance of supporting scientific studies in the fields of brain health and age-related cognitive decline. By collaborating with researchers and experts, we aim to contribute valuable insights that can inform our ingredient choices and the development of effective formulations. Our commitment to supporting and sharing peer-reviewed research ensures that our products are evidence based, ultimately benefiting the health and well-being of our members.
For more information on collaborations, feel free to reach out to us directly on our Contact page.
A detailed list of citations of our featured peer-review articles is available below.
Khouchlaa, A., Khouri, S., Hajib, A., et al. (2024), Health benefits, pharmacological properties, and metabolism of cannabinol: A comprehensive review. Industrial Crops and Products, 204: 118359. https://doi.org/10.1016/j.indcrop.2024.118359
Liang, Z. and Maher, P. (2022), Targeting mitochondria for healthy brain aging: a case study of non-psychoactive cannabinoids to rescue mitochondrial dysfunction in Alzheimer’s disease. Alzheimer’s Dement., 18: e062544. https://doi.org/10.1002/alz.062544
Kolobaric, A.; Saleska, J.; Hewlings, S.J.; Bryant, C.; Colwell, C.S.; D’Adamo, C.R.; Chen, J.; Pauli, E.K. A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBN™ for Improving Sleep. Pharmaceuticals 2024, 17, 977. https://doi.org/10.3390/ph17080977
Liang, Z., Soriano-Castell, D., Kepchia, D., Duggan, B. M., Currais, A., Schubert, D., & Maher, P. (2022). Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors. Free Radical Biology and Medicine, 180, 33-51.
https://doi.org/10.1016/j.freeradbiomed.2022.01.001
Liang, Z., Currais, A., Soriano-Castell, D., Schubert, D., & Maher, P. (2021). Natural products targeting mitochondria: Emerging therapeutics for age-associated neurological disorders. Pharmacology & Therapeutics, 221, 107749.
https://doi.org/10.1016/j.pharmthera.2020.107749
Schubert, D., Kepchia, D., Liang, Z. et al. Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease. Mol Neurobiol 56, 7719–7730 (2019). https://doi.org/10.1007/s12035-019-1637-8
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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